Measuring Athletes* Risk of Cardiovascular Events - Exercise-Induced Cardiac Troponin Release and Coronary Atherosclerosis in Amateur Athletes

Measuring Athletes* Risk of Cardiovascular Events - Exercise-Induced Cardiac Troponin Release and Coronary Atherosclerosis in Amateur Athletes - MARC-EXERSCIENCE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49634

Enrollment

Registered

2020-08-05

Start date

2020-10-08

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease Coronary atherosclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Participation in MARC-2 study (so recent information about coronary atherosclerosis is known). - Availability of recent (

Exclusion criteria

Exclusion criteria: - Unable to give informed consent - Presence of a stent in any coronary artery or undergone coronary artery bypass surgery - Not cleared for exercise training by a cardiologist following the MARC-2 study coronary CT-scan findings - Absolute contra-indications for an exercise test (as indicated by the Standard Operating Procedure guidelines of the department of Physiology (see page 16 of C1 protocol)). - Participation in an interventional study targeting cardiovascular health

Design outcomes

Primary

Measure	Time frame
The primary outcome is cardiac troponin concentration at 0/30/60/120 and 180 minutes after exercise cessation.	—

Secondary

Measure	Time frame
Secondary endpoints are other cardiac biomarkers (B-type natriuretic peptide, soluble ST-2, cardiac myosin-binding protein C and Galectin-3) collected at the same timepoints. Furthermore, exercise-specific physiological parameters (including blood pressure, saturation and heart rate), biochemical biomarkers (calcium, parathyroid hormone, phosphate and magnesium) and measures of vascular function (Carotid Artery Reactivity test) are collected to gain more insight into the potential underlying mechanisms of accelerated coronary atherosclerosis in amateur athletes.	—

Measure

Time frame

Secondary endpoints are other cardiac biomarkers (B-type natriuretic peptide, soluble ST-2, cardiac myosin-binding protein C and Galectin-3) collected at the same timepoints. Furthermore, exercise-specific physiological parameters (including blood pressure, saturation and heart rate), biochemical biomarkers (calcium, parathyroid hormone, phosphate and magnesium) and measures of vascular function (Carotid Artery Reactivity test) are collected to gain more insight into the potential underlying mechanisms of accelerated coronary atherosclerosis in amateur athletes.

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Countries

Netherlands

Outcome results