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Excitatory/Inhibitory imbalance in autism spectrum disorder

Excitatory/Inhibitory imbalance in autism spectrum disorder - Equilibrium

Status
Unknown
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON49625
Enrollment
60
Registered
2020-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ASD autism

Interventions

None listed

Sponsors

Radboud Universitair Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18 years or older Dutch speaking Normal or corrected-to-normal vision Willingness and ability to understand nature and content of the study IQ > 70 An established clinical diagnosis of autism spectrum disorder according to the DSM-5 criteria (patient group only)

Exclusion criteria

Exclusion criteria: History of brain surgery or epilepsy History of neurological treatment Any acute or chronic neurological disorders. Pregnancy Claustrophobia MRI incompatibility (metal parts in upper body, implants, medical devices or medicinal plasters) There is presence of a diagnosis of psychosis or bipolar disorder (patient group) There is presence of any DSM-5 axis I or axis II psychiatric disorders (control group)

Design outcomes

Primary

MeasureTime frame
ASD symptoms (continuous measures of repetitive behavior problems and abnormal sensory processing as measured with the Repetitive Behaviour Scale and the Short Sensory Profile) and the degree to which these symptoms are associated with MRI-based functional and neurochemical measures in the anterior cingulate cortex (ACC) and visual cortex (V1) will be investigated.

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)