diabetes insulin resistance
Conditions
Interventions
ischemia (8 minutes) and prolonged fasting (36h)
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age: 18-40 years - BMI: 18-25 kg/m2 - Generally healthy
Exclusion criteria
Exclusion criteria: - regular (every day more than three cigarettes) smoking Par-ticipants who smoke by occasion (for instance during a party) but not daily are not ex-cluded from participation - Alcohol consumption (men > 4 units per day; women > 3 units per day) - Use of anti-coagulants or other medication known to hamper blood coagulation - Contraindications for MRI scans - Participation in other (intervention) studies - Subjects who do not want be informed about unexpected medical findings, or do not wish that their physician be informed cannot participate in the study - Any condition, disease, abnormal laboratory test result or medication that, in the opinion of the investigator and the dependent physician, would interfere with the study outcome, affect trial participation or put the subject at undue risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NAD+ concentration as measured by 31P-MRS before/after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint is NAD+ as determined in muscle biopsies. | — |
Countries
Netherlands
Outcome results
None listed