Reduced Microvascular Blood Volume as a Driver of Coronary Microvascular Disease in Patients with Non Obstructive Coronary Artery Disease

Reduced Microvascular Blood Volume as a Driver of Coronary Microvascular Disease in Patients with Non Obstructive Coronary Artery Disease - MICORDIS study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49617

Enrollment

Registered

2018-08-07

Start date

2018-10-16

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary microvascular dysfunction Non obstructive coronary artery disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patient group: - Age > 40 years - Signed informed consent - Stable and chronic symptoms suggesting ischemic heart disease - NOCAD on coronary angiography: coronary artery stenosis 0.80 - Prior transthoracic echocardiographic assessment Control group: - Age > 40 years - Signed informed consent36 bgc

Exclusion criteria

Exclusion criteria: - Age > 80 years - Obstructive coronary artery disease, defined as more than 50% obstruction of any coronary artery - FFR 100 and eGFR

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the statistical difference in MBV between NOCAD patients and healthy controls. We compare MBV between groups at baseline, during hyperinsulinemia and during increased cardiac contraction. MBV is measured using MCE. Hyperinsulinemia is induced by a two hour HE-clamp and cardiac stress with increased contraction is induced by the infusion of dobutamine.	—

Secondary

Measure	Time frame
The insulin-mediated capillary recruitment (MBV) is the difference in MBV at baseline and after HE-clamp. Insulin-resistance is calculated using the M-value of the last half hour of HE-clamp. 1. MBV, MBF, MBV, baseline characteristics, cardiovascular risk factors, questionnaire results, blood parameters and measurement indexes compared between males and females from the patient and control group. 2. Differences in MBV and MBF between baseline and after HE-clamp of the patient and control group and differences in MBV and MBF between baseline and after dobutamine stress of the patient and control group. 3. Baseline characteristics, cardiovascular risk factors, questionnaire results and measurement indexes compared between the patient and control group. 4. MBV, MBF and *MBV compared between insulin resistant subjects and non-insulin resistant subjects. 5. Correlation between MBV (+other related variables) measured with MCE and MBV measured with CMR. 6. Protein expression and phosphorylation of microvascular endothelial cells compared between the patient and control group.	—

Measure

Time frame

The insulin-mediated capillary recruitment (*MBV) is the difference in MBV at baseline and after HE-clamp. Insulin-resistance is calculated using the M-value of the last half hour of HE-clamp. 1. MBV, MBF, *MBV, baseline characteristics, cardiovascular risk factors, questionnaire results, blood parameters and measurement indexes compared between males and females from the patient and control group. 2. Differences in MBV and MBF between baseline and after HE-clamp of the patient and control group and differences in MBV and MBF between baseline and after dobutamine stress of the patient and control group. 3. Baseline characteristics, cardiovascular risk factors, questionnaire results and measurement indexes compared between the patient and control group. 4. MBV, MBF and *MBV compared between insulin resistant subjects and non-insulin resistant subjects. 5. Correlation between MBV (+other related variables) measured with MCE and MBV measured with CMR. 6. Protein expression and phosphorylation of microvascular endothelial cells compared between the patient and control group.

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Countries

Netherlands

Outcome results