cerebral hemorrhage hemorrhagic stroke
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Supratentorial non-traumatic ICH confirmed by CT, without a confirmed causative lesion on admission CT-angiography (e.g. aneurysm, AVM, DAVF, cerebral venous sinus thrombosis) or other known underlying lesion (e.g. tumour, cavernoma); 3. Minimal haemorrhage volume of 10mL; 4. Inclusion within 24 hours after symptom onset; 5. Patient*s or legal representative*s informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe infection at admission, requiring antibiotic treatment; 2. Use of immunosuppressive or immune-modulating therapy at admission; 3. Pre-stroke modified Rankin Scale score >= 3; 4. Severe ICH, unlikely to survive the first 72 hours (defined as Glasgow Coma Scale score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is perihematomal oedema (measured as oedema extension distance on MRI at day 7), which will be correlated with perihematomal uptake of 18F-DPA-714 on PET imaging at day 3 as a measure of neuroinflammation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are the association between and the perihematomal uptake of 18F-DPA-714 on PET imaging at day 3 and blood barrier leakage Ktrans as measured with DCE-MRI on day 7. Furthermore the correlation with serum inflammation markers (comparing day 1, 3 and 7 to baseline) will be assessed. | — |
Countries
Netherlands
Outcome results
None listed