Osteoarthritis Osteoarthritis
Conditions
Interventions
Patients will be invited to fill out pain questionnaires pre-operative, and at 6 weeks, 6 months, 1 year after TKR. Pain characteristics and neuroplastic changes will be assessed by quantitative senso
 
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: • At least 18 years of age • OA-patients: Be eligible for TKR under spinal anaesthesia, according to routine clinical practice. • Controls: Be eligible for anterior cruciate ligament (ACL) operation under spinal anaesthesia, according to routine clinical practice.• Able and willing to give written informed consent
Exclusion criteria
Exclusion criteria: • Auto-immune disease or diabetes mellitus because they may also affect the sensory system. • Use of (pain) medication other than acetaminophen/paracetamol, NSAIDs and/or opioids. • Polyneuropathy or other neurologic disease that might affect outcome measures. • Major cognitive or psychiatric disorders. • Problems with communication (language, deafness, aphasia etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will dichotomize the cohort on the following three outcome parameters to assess whether the the biological measurements/mediators are different between the dichotomised subgroups. Knee VAS and widespread pain are measured prior to TKR, and at 6 weeks, 6 months, and 1 year after TKR but only specific timepoints are used yo dichotomize the cohort. 1. Self-reported knee pain severity at the time of TKR: severe pain (VAS >=40/100 at rest) versus limited pain (knee VAS 10) versus no persisting pain (knee VAS at rest = | — |
Secondary
| Measure | Time frame |
|---|---|
| Independent continues variables: -Quantitative sensory testing (QST) QST will be conducted at the index knee and 2 other body area*s (arm and lower leg) and includes. 1. cold pain thresholds (index knee, lower leg, arm); 2. heat pain thresholds (index knee, lower leg, arm); 3. pressure pain threshold to cutaneous blunt stimuli (index knee, lower leg, arm); 4. cuff pressure pain threshold (both lower legs); 5. Summation of Thermal (heat) (index knee; arm); 6. Summation of Mechanical cuff pressure pain (lower leg); 7. Conditioned pain modulation - Pain assessment, questionnaires: 1. The Knee Injury and Osteoarthritis Outcome Score (KOOS) 2. Measure of intermittent and constant osteoarthritis pain (ICOAP). 3. Graded Chronic Pain Scale (GCPS) 4. Paindetect Other biological measures -Metabolomics: -Innervation knee tissue | — |
Countries
Netherlands
Contacts
Public ContactH.L.D.M. Willemen
Universitair Medisch Centrum Utrecht
Outcome results
None listed