Stress-related mental health problems
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participants are healthy students (18-25 years old) who have experienced at least three life events which were each evaluated as burdening. Participants have a total GHQ (i.e. general health questionnaire) score * 20. Volunteers are proficient in the Dutch language.
Exclusion criteria
Exclusion criteria: The participant currently meets criteria of a relevant psychiatric disorder except for a mild depressive episode (ICD F32.1), tobacco dependence (ICD F12) and substance abuse as established using the Mini-International Neuropsychiatric interview. The participant has met criteria for a relevant psychiatric disorder except for a mild depressive episode (ICD F32.1), tobacco dependence (ICD F12), and a substance abuse in the past 9 months. The participant has ever been diagnosed with a severe mental or organic disorder that affects neurodevelopment due to its pathological mechanism or treatment. The subject*s body mass index is lower than 18 or higher than 27. The participant is not eligible for functional magnetic resonance imaging. The participant took any psychoactive substances 4 weeks prior to Baseline Day 1 and the MRI appointment. The participant is not eligible to wear the Chill+. The participant is not free of COVID-19 related symptoms.The participant is currently in psychiatric treatment. The participant receives hormonal treatment other than oral contraceptives and/or takes steroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is dynamic stress resilience (i.e. mental health maintenance despite stressor exposure), as measured with a residuals-based stressors reactivity score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Several parameters are studied to unravel the time-varying, individually variable and interactive engagement of the biological, psychological and social resilience factors, including: biological parameters, psychological questionnaires, neuroimaging, and ecological momentary & physiological assessments. | — |
Countries
Netherlands
Outcome results
None listed