development-of-the-brain Neurological-development
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: - Singleton pregnancy - Normal second trimester ultrasound (absence of abnormalities on ultrasound) - No use of alcohol, drugs or other psychoactive substances during pregnancy - Age >= 18 years - Gestational age 18-36 weeks
Exclusion criteria
Exclusion criteria: - Obstetric history of intra-uterine growth restriction or intra-uterine fetal demise - Serious underlying maternal medical condition - Use of teratogenic medication during pregnancy - Congenital abnormalities detected in the first year of life
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Brain age of healthy control fetuses, especially in the third trimester (cortical folding in the brain) 2. Speed of maturation of healthy control fetuses, especially in the third trimester | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Brain perfusion of healthy control fetuses 2. Growth trajectories of brain structures, 3. Brain volume of healthy control fetuses 4. Collection of placentas and biomaterial of the umbilical cords for storage for future research. The biomaterials will be stored in the LUMC Biobank Verloskunde. The regulations of the LUMC Biobank Verloskunde will be applicable | — |
Countries
Netherlands
Outcome results
None listed