diabetes mellitus sugar
Conditions
Interventions
Subjects are followed for a total of 10 days. Six of those 10 days are the
"intervention days" on which the subjects must adhere to rules. Subjects
follow a schedule with set times at which they eat
Sponsors
RIVM
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - BMI 18.5-30 kg/m2 - 18-65 years old - Subjectively health
Exclusion criteria
Exclusion criteria: - Illiteracy - Not being able to give informed consent - Do not have a doctor - Use of medicines that can influence glucose levels: such as beta-adrenergic receptor antagonists ('beta-blockers') - Pregnancy, breastfeeding, women who are actively trying to conceive - Acute and / or chronic disease that prevents the test subject from adhering to the research protocol. - Metabolic and / or hormonal disorders, such as diabetes mellitus - Swallowing problems, delayed stomach emptying - Allergies for the standard snack, such as gluten intolerance - Practicing extreme sports (for example, marathon, triathlon) - Practicing a very physically demanding job such as in construction. - Smoking - Known allergic skin reaction during the use of continuous glucose monitoring or patches in general
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The continuous glucose values **are determined with Dexcom G6 glucose monitors that the subjects carry with them for 10 days. The primary endpoint of the study is the difference in the incremental area under the glucose response curve: the "incremental area under the curve" (iAUC) at different times of the day around the consumption of standardized snacks. During the entire 10-day period, the test subjects keep a food diary through an app. | — |
Secondary
| Measure | Time frame |
|---|---|
| To explore the relationship with physical activity and nutrition, the test subjects also wear an ActiGraph wGT3X BT accelerometer. | — |
Countries
Netherlands
Outcome results
None listed