CHANCE study - Detecting early heart failure by using a highly accelerated novel acquisition protocol in cardiac MRI

CHANCE study - Detecting early heart failure by using a highly accelerated novel acquisition protocol in cardiac MRI - CHANCE Study - Earlier recognition of cardiovascular diseases

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49539

Enrollment

216

Registered

2020-07-01

Start date

2021-05-05

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure HFpEF

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Multiple clinically established characteristics of HFpEF

Exclusion criteria

Exclusion criteria: Patients with a pacemaker, internal cardioverter-defibrillator or cardiac resynchronization device can not undergo MRI. Additional exclusion criteria: underaged (

Design outcomes

Primary

Measure	Time frame
This research will be the first clinical application i.e. first steps of the clinical Health Technology Assesment on subjects/patients after the developing-phases. Therefore, the primary endpoint is testing a new medical device on validity, repeatability and reproducibility. To reach the endpoints of validity, repeatability and reproducibility, the goal of current proposal is measuring multiple parameters composed in new protocols in a very short time period. These multiparametric CHANCE protocols include parameters defined as, but are not restricted to the following parameters: Primary: 1. Functional parameters a. Left/right ventricle: end-systolic and end-diastolic volumes, cardiac outputs, ejection fractions, left ventricle mass index b. Left atrium: ejection fractions, area 2. Contrast parameters a. Native myocardial & blood T1-values b. Native myocardial T2 & T2* values c. Post GBCA myocardial & blood T1 values	—

Measure

Time frame

This research will be the first clinical application i.e. first steps of the clinical Health Technology Assesment on subjects/patients after the developing-phases. Therefore, the primary endpoint is testing a new medical device on validity, repeatability and reproducibility. To reach the endpoints of validity, repeatability and reproducibility, the goal of current proposal is measuring multiple parameters composed in new protocols in a very short time period. These multiparametric CHANCE protocols include parameters defined as, but are not restricted to the following parameters: Primary: 1. Functional parameters a. Left/right ventricle: end-systolic and end-diastolic volumes, cardiac outputs, ejection fractions, left ventricle mass index b. Left atrium: ejection fractions, area 2. Contrast parameters a. Native myocardial & blood T1-values b. Native myocardial T2 & T2* values c. Post GBCA myocardial & blood T1 values

—

Secondary

Measure	Time frame
Secondary: 1. Contrast parameters a. Endogenous myocardial T1* relaxation times b. 4D-flow velocities. c. Cardiac diffusion MRI	—

Countries

Netherlands

Outcome results