pleural effusion Pus in the area between the lungs
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years Diagnosed with pleural empyema or complicated parapneumonic effusion, based on the criteria mentioned below, and in need of pleural fluid drainage. o presence of pus or positive Gram*s stain or culture from the pleural fluid. o pleural pH1000 IU/L Receiving IV amoxicillin 1000mg 4 times daily or amoxicillin-clavulanic acid 1000/200mg 4 times daily; dosage if necessary adapted to renal function Able and willing to give informed consent (or consent by family member or legal representative)
Exclusion criteria
Exclusion criteria: Critically ill patients admitted to the ICU, or patients of the general ward who became critically ill and got transferred to the ICU during the duration of the study. Pre-existing ipsilateral pleural effusion or other cause of pleural effusion (e.g. cancer) more likely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endpoints are the probability of target attainment in pleural fluid of intravenous amoxicillin(-clavulanic acid). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is the penetration ratio of the antibiotics from blood plasma to pleural fluid, expressed as the fAUC0-6/8 of pleural fluid divided by the fAUC0-6/8 of plasma. | — |
Countries
Netherlands
Outcome results
None listed