Cardiovascular disease hypercholesterolemia
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients: - Aged 18 years or older - They are eligible for participation if they fulfil the criteria for *possible* FH (3-5 points), *probable* FH (6-8 points) or *definitive* FH (>8 points), according to the Dutch Lipid Clinic Network diagnostic criteria for familial hypercholesterolemia and untreated LDL levels >4.9 mmol/l and requiring lipid lowering treatment according to the treating physician - No previous cardiovascular events - Written informed consent Control subjects: - Age 18 years or older - LDL cholesterol
Exclusion criteria
Exclusion criteria: - Current lipid lowering treatment or treatment with lipid lowering drugs in the past year. - Age 38.5) - Previous vaccination within 1 months prior to study entry - Chronic use of anti-inflammatory drugs such as NSAIDs (acetylsalicylic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this study we want to evaluate the long term effect of cholesterol lowering treatment (1year) on the circulating innate immune cell in patietns with familial hypercholesterolemia. This most important question is if long term treatment can effect the trained immunity phenotype. | — |
Secondary
| Measure | Time frame |
|---|---|
| nvt | — |
Countries
Netherlands
Outcome results
None listed