Cortical activation patterns measured with functional near-infrared spectroscopy (fNIRS) during freezing of gait triggered by turning and passing doorways in Parkinson's disease.

Cortical activation patterns measured with functional near-infrared spectroscopy (fNIRS) during freezing of gait triggered by turning and passing doorways in Parkinson's disease. - fNIRS cortical activation patterns during freezing of gait.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49479

Enrollment

Registered

2019-09-05

Start date

2020-09-16

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - idiopathic Parkinson's disease - experiencing freezing of gait more than once a day

Exclusion criteria

Exclusion criteria: - comorbidities that cause severe gait impairments - comorbidities that interfere with fNIRS recording (i.e. previous brain surgery, structural cerebral lesions) - inabilty to comply with the protocol (inability to walk 150 m or make a half turn unaided, inability to walk 10 seconds without experiencing freezing of gait, severe cognitive impairments)

Design outcomes

Primary

Measure	Time frame
The main study parameter is change in fNIRS activity (i.e. oxygenated hemoglobin and de-oxygenated hemoglobin) relative to baseline in 10 brain regions: the sensorimotor cortex, the supplementary motor area, the premotor cortex, the dorsolateral prefrontal cortex, and the posterior parietal (in both hemispheres).	—

Secondary

Measure	Time frame
/	—

Countries

Netherlands

Outcome results