Exploring the mechanism of action of low-dose glucocorticoids: a study of oral versus parenteral glucocorticoids.

Exploring the mechanism of action of low-dose glucocorticoids: a study of oral versus parenteral glucocorticoids. - GC-first-pass

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON49468

Enrollment

Registered

2020-05-14

Start date

2020-03-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polymyalgia rheumatica psoriatic arthritis Reumatoid arthritis

Interventions

Main study: Patients will be randomised to two groups according to the order of drug administration. One group will receive 4 days once daily 5, 7.5 or 10 mg prednisolone (dose to be determined in d

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Reumatoid arthritis, polymyalgia rheumatica or psoriatic arthritis according to the treating physician -Elevated ESR (>=30 mm/h)

Exclusion criteria

Exclusion criteria: Difficult to measure a decreased ESR -Current or recent (

Design outcomes

Primary

Measure	Time frame
Primary outcome measure is ESR.	—

Secondary

Measure	Time frame
Secondary outcomes are C-reactive protein (CRP), cortisol, adrenocorticotropic hormone (ACTH) and disease activity (based on Rapid3 questionnaire). Stored serum samples may be used for further analysis of inflammatory cytokines as exploratory endpoints.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)