kanker-gerelateerde vermoeidheid cancer-related fatigue
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For all participants (healthy and patients): • Written informed consent • Male • Age between 18 and 50 yrs • Sufficient command of the Dutch language (to answer questionnaires) For all patients: • Unilateral orchiectomy • BEP or EP treatment regimen (for sugery+chemo group) • No patients who received radiotherapy because of non-comparable tumor-types and treatment side-effects
Exclusion criteria
Exclusion criteria: For all participants (healthy and patients): • Presence of acute infection or inflammation on day of testing (body temperature >38) • Current use of prescribed psychotropic, pain or anti-inflammatory drugs • (history of) long-term (> 6 months) daily use of over-the-counter NSAIDs (ibuproven, diclofenac, naproxen) (for patients: besides those used during cancer-treatment) • Current use of over-the-counter corticosteroids, anti-histamic or anti-inflammatory drugs (participants that use corticosteroid moistures or hay-fever drugs are asked to not use it on the testing day) • Obesity (BMI>30) • (history of) metabolic disease (e.g. diabetes) • (history of) cardiovascular events • (history of) neurological or psychiatric symptoms/disease • (history of) chronic inflammatory disease (e.g. rheumatoid arthritis, Crohns disease) • (history of) hypo/hyperthyroide • (history of) chronic pain (>6 months) (for patients before diagnosis) • (history of) chronic fatigue syndrome or fibromyalgia (for patients before diagnosis) • (history of) hypogonadism/ hormonal disturbance or suppletion (for patients before diagnosis) • (history of) renal failure For all patients • Patients who received radiotherapy because of non-comparable tumor-types and treatment side-effects For all healthy participants • Severe fatigue (CIS-fatigue
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Individual weightings of effort and reward sensitivity, as measured with effort/reward weighting task • Subjective mood ratings (including but not limited to fatigue, depressive mood, and anxiety) (All questionnaires are described below) • Plasma cytokine concentration profiles (including but not limited to CRP, TNFa, IL-1 and IL-6) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Cortisol Awakening Response (CAR) • Potential health-related, stress-related, and psychosocial predictors (All questionnaires are described below) • General neurocognitive functioning (Amsterdam Cognition Scan (ACS)) for replication of previous studies (Schagen et al 2008, Stouten-Kemperman et al 2015b) - reward and punishment based learning | — |
Countries
Netherlands
Outcome results
None listed