essential tremor tremor
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - For the index patient: diagnosis of essential tremor syndrome by neurologist, in line with the consensus statement put forward by the Tremor Investigation Group of the Movement Disorders Society and a minimum age of 18 years. - For the family: a minimum of 3 affected relatives, belonging to a minimum of 2 generations, willing to participate.
Exclusion criteria
Exclusion criteria: - Part A, if the patient has a silver allergy - Part A, if the patient has a pacemaker - Part B, if the patients alcohol history is indicative of (previous) alcohol abuse - Part B, if the patient is pregnant or breastfeeding - Part B, if the patient uses medication which is contraindicated in combination with alcohol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this study we will try to identify a familial phenotype of essential tremor in our population, based on clusters of the discovered familial features. Based on our recently published review (4) we will address the following features of interest: age at onset, cranial tremor, dystonia, alcohol responsivity and tremor frequency. | — |
Secondary
| Measure | Time frame |
|---|---|
| Features of secondary interest are: - Disease progression - Cerebellar signs (intention tremor via finger-to-nose manoeuvres, via finger-to-finger manoeuvres, tandem gait difficulty) - Parkinsonism (bradykinesia, rigidity) - Tremor severity (Fahn-Tolosa-Marin Essential Tremor Rating Scale part A and B, visual analogue scale) - Neurophysiological features (frequency variability, coherence analysis) - Discrepancies between self-reported and test-based alcohol responsivity | — |
Countries
Netherlands
Outcome results
None listed