tissues and organs
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent - Age: 18-90 years - Healthy subject (defined as a volunteer who is not referred to Erasmus MC with signs and symptoms of disease)
Exclusion criteria
Exclusion criteria: - No informed consent - Subjects refusing to undergo testing - Subjects with obstructive or resistive lung disease whose PaCO2 at rest is greater than 50mmHg or whose venous serum bicarbonate is greater than 26 mEq/L - Subjects with pre-existing respiratory acidosis - Subjects who require portable oxygen at rest or with exercise - Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath - Subjects with severe heart failure or restrictive lung disease with resting respiratory rate over 15 breaths/min - Subjects with a typical contra-indication to an MRI exam - Subjects with metal implants - Woman who are pregnant or lactating - Having any physical or mental status that interferes with the informed consent procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Protocols for respiratory challenges will be optimised by trading off the duration and strength of respiratory stimulations with parameters of MRI quality to assess the vascular responses of interest (artefacts, signal to noise, contrast to noise, reproducibility, accuracy). | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed