scientific investigation of healthy subjects healthy
Conditions
Interventions
None listed
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy adult subjects with no history of neurological disorder/disease and no counter-indications to 3 Tesla MRI or to atomoxetine, and no personal relationship with the researchers will be included in this study. All participants will be right-handed with normal vision or contact lenses.
Exclusion criteria
Exclusion criteria: Significant history of head trauma, premature birth, learning disabilities, neurological or psychiatric illness. Heart arrhythmia, glaucoma, congenital eye diseases, hyperopia, myopia, hypertension and use of anti-depressants or psychotropic medication and possible pregnancy (in adult females). MRI contra-indications, including metal implants and claustrophobia. Smoking more than five cigarettes a day - to avoid nicotine withdrawal effects during the study. Alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| * Behavioural measures: effect of atomoxetine on accuracy and reaction time. * Brain activity measures: effect of atomoxetine on task-related evoked BOLD signal, measures of information flow, and correlation measures between BOLD time courses in regions of interest. * Computational measures: model fit to empirical fMRI data under different levels of atomoxetine. | — |
Secondary
| Measure | Time frame |
|---|---|
| * Psychometric measures: state anxiety, trait anxiety, emotional arousal, as regressors for behavioural and fMRI data. * Psychophysiological measures: task-related and task-unrelated changes in pupil size, as regressors for behavioural and fMRI data.. * Physiological measures: salivary cortisol and alpha amylase, as regressor for behavioural and fMRI data. | — |
Countries
Netherlands
Outcome results
None listed