Fysiologie van natriumbalans Non-osmotic sodium accumulation Salt regulation
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: Healthy, male children undergoing a circumcision Parents / caregivers capable of giving written informed consent and able to comply with the requirements listed in the informed consent form.
Exclusion criteria
Exclusion criteria: Unwillingness from the parents to let their child participate in the study Parents who are not capable of giving written informed consent and able to comply with the requirements listed in the informed consent form Contraindication for circumcision One or both parents who are not capable of reading and understanding the Dutch patient information letter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint will be the sodium content of the skin, expressed in mmol per g dry weight in correlation with cardiovascular risk factors. | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin GAG composition, residing macrophages, capillary, and lymphatic density (i.e., skin changes that relate to a high sodium-induced BP rise) and BP represent secondary outcome measures. | — |
Countries
Netherlands
Outcome results
None listed