cerebral perfusion cognitive function Endstage renal disease renal failure
Conditions
Interventions
A longer HD session (8 hours) will be compared with a conventional HD session
(4 hours)
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Conventional HD (for part A): Treatment with conventional HD 3 times per week 4 hours - Nocturnal HD (for part B): Treatment with nocturnal HD 3 times per week 8 hours - Age >18 years - Presence of a well-functioning central venous catheter or AV fistula or graft with a vascular access flow of >400 mL/min
Exclusion criteria
Exclusion criteria: - Unable to obtain an optimal transcranial acoustic window during dialysis - Severe cognitive impairment - Medical history of (major) psychiatric illness, such as psychosis, schizophrenia, severe personality disorder or depression with vital signs, that could affect cognitive performance - Non-adherence to the dialysis procedure - Insufficient proficiency in the Dutch Language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is the difference in intradialytic cerebrovascular hemodynamic changes (cerebral blood flow velocity) between the longer HD (extended HD and NHD; 8 hours) vs. CHD session. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes of the study are the differences between the longer HD vs. CHD sessions regarding the following parameters: -Systemic hemodynamic changes (heart rate, stroke volume, cardiac output and BP) -Cognitive function -Cerebrovascular autoregulatory capacity -BP variability, i.e. baroreflex sensitivity (very short-term BP variability), standard deviation and coefficient of variation of the NIBP values (short-term BP variability; only for part A) -Cardiovascular autonomic (parasympathetic and sympathetic) function | — |
Countries
Netherlands
Outcome results
None listed