diabetes type-2
Conditions
Interventions
In the experimental groups, participants will receive 6 intranasal
applications of 20 IU insulin during the acquisition day and 6 applications of
a placebo nasal spray during the evocation day. In t
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For patients: - Diagnosis of diabetes mellitus type 2 - Taking metformin or participating in a life style intervention (e.g., diet)
Exclusion criteria
Exclusion criteria: - Use of insulin or, insulin stimulating medications ; - Use of medication that influences glucose metabolism, for example, corticosteroid medication, chemotherapy, beta-blockers; - Diagnosis of an acute not-infectious disease (degenerative diseases, malignant neoplasms such as cancer, diabetes type-1, auto-immune diseases); - Diagnosis of an acute infectious diseases (such as meningitis, hepatitis B, bacterial pneumonia); - Current diagnosis of a mental disorder; - Chronic and/or acute rhinitis, anatomic deviations of the nose; - Substance abuse (e.g., drugs or alcohol); - Pregnancy or an intention to get pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameters are blood insulin and glucose levels during the evocation day in the experimental patients group versus the control patients group. Insulin and glucose will be measured 8 times: at baseline, after each of the 6 applications of nasal spray and 15 minutes after the last spray administration. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondly, we investigate the effects of conditioning with insulin on C-peptide, hunger, approach-avoidance tendencies, food intake and cognitive functioning measured with a memory task. Finally, a comparison between patients and healthy participants will be made on the study outcomes. | — |
Countries
Netherlands
Outcome results
None listed