Spieropbouw na inspanning building muscle protein Muscle protein synthesis
Conditions
Interventions
All subjects will perform a single bout of whole-body resistance-type exercise.
Subsequently, subjects will ingest a beverage containing water, low glycated
milk protein (5% blocked lysine), or high
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Males - Aged between 18-35 years - Healthy, recreationally active (participating in recreational sports activities * 1 and * 6 h per week, with a maximum of 2 h resistance-type exercise) - 18.5 * BMI * 30 kg/m2 - No physical limitations (i.e. able to perform all activities associated with daily living in an independent manner).
Exclusion criteria
Exclusion criteria: - Smoking - Lactose intolerant or allergies to milk proteins - Regular consumption of protein supplements (e.g. protein powders) - Musculoskeletal disorders - Metabolic disorders - Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications). - Chronic use of gastric acid suppressing medication or anti-coagulants - Recent (
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be mixed muscle protein synthesis rates over the full assessment period (6h h), as determined using contemporary stable isotope tracer methodology combined with multiple muscle and blood samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the impact of low versus high protein glycation on peak plasma lysine concentration, overall plasma amino acid responses, plasma insulin-, and glucose responses. | — |
Countries
Netherlands
Outcome results
None listed