Image guidance in neurosurgery: Flatpanel-Detector Parenchymal Blood Volume imaging and Magnetic Resonance - Dynamic Contrast Enhanced perfusion imaging in meningiomas

Image guidance in neurosurgery: Flatpanel-Detector Parenchymal Blood Volume imaging and Magnetic Resonance - Dynamic Contrast Enhanced perfusion imaging in meningiomas - Image guidance in neurosurgery: FD-PBV and MR-DCE in meningeomas

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49397

Enrollment

Registered

2021-05-05

Start date

2022-06-23

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

meningeal tumor Meningioma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Diagnosed with an intracranial meningioma, located above the tentorium in convexity or falx. - Scheduled for resection via craniotomy, including standard pre-operative MRI. - Age >= 50 years

Exclusion criteria

Exclusion criteria: - History of intracranial surgery - History of major stroke with residual morbidity, significantly altering intracranial hemodynamics (e.g. large vessel occlusion) - Impaired kidney function (eGFR

Design outcomes

Primary

Measure	Time frame
Primary objective of this study is to assess the feasibility of FD-PBV imaging in meningiomas; image quality of scans including reconstructed colour coded maps and vascular images will be evaluated by neurosurgeons and an experienced neuroradiologist using a standardized scoring form. Besides a descriptive analysis of this new application, yielded images and hemodynamic parameters will be compared with MR-DCE perfusion imaging and current literature.	—

Measure

Time frame

Primary objective of this study is to assess the feasibility of FD-PBV imaging in meningiomas; image quality of scans including reconstructed colour coded maps and vascular images will be evaluated by neurosurgeons and an experienced neuroradiologist using a standardized scoring form. Besides a descriptive analysis of this new application, yielded images and hemodynamic parameters will be compared with MR-DCE perfusion imaging and current literature.

—

Secondary

Measure	Time frame
Secondary endpoints of this study include: - Added value in neurosurgery, assessed by a neuroradiologist and operating neurosurgeon, - Practical workflow, extra time spent under general anaesthesia, effective contrast/radiation dose and learning curve, - (Intraclass) correlation coefficients calculated of the obtained hemodynamic parameters between imaging techniques.	—

Countries

Netherlands

Outcome results