Peripheral and Central Nervous System Contributions to the Subjective Experience of Emotions

Peripheral and Central Nervous System Contributions to the Subjective Experience of Emotions - PNS vs. CNS in Experimental Panic

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON49383

Enrollment

Registered

2021-01-18

Start date

2021-02-18

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety attacks Panic attack

Interventions

In 3 different sessions, participants will undergo one 35% CO2 inhalation per session, preceded by oral administration of atenolol, metoprolol or a placebo. Each participant will receive each condit

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18-55 years old, healthy subject, adequate sensitivity to CO2 (as tested in the screening)

Exclusion criteria

Exclusion criteria: mental or physical disorder/illness, pregnant, relatives with panic disorder

Design outcomes

Primary

Measure	Time frame
Main study parameters are changes (from pre- to immediately post- CO2 inhalation) per condition (atenolol, metoprolol, placebo) in fear, discomfort and panic symptom ratings, as measured by questionnaires.	—

Secondary

Measure	Time frame
Secondary outcomes are changes in physiological parameters (e.g., skin conductance, heart rate).	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)