The effect of clonal hematopoiesis on trained immunity; an exploratory study

The effect of clonal hematopoiesis on trained immunity; an exploratory study - CHIP in TRIM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49356

Enrollment

Registered

2020-06-11

Start date

2021-05-19

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerisis obesity

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Participant of the 300OB study - Mutation in TET2, DNMT3A, or no driver mutation - Informed consent

Exclusion criteria

Exclusion criteria: - Current use of immunomodulatory drugs.

Design outcomes

Primary

Measure	Time frame
60 ml of blood will be drawn by venepuncture to measure cytokine production capacity and the susceptibility to develop trained immunity.	—

Secondary

Measure	Time frame
In addition, within the subjects with the driver mutations, single cell RNA sequencing will be performed to explore the hypothesis that monocytes with a mutation are more amenable to trained immunity.	—

Countries

Netherlands

Outcome results