The influence of symptom provocation on glutamate in obsessive-compulsive disorder - a functional magnetic resonance spectroscopy study

The influence of symptom provocation on glutamate in obsessive-compulsive disorder - a functional magnetic resonance spectroscopy study - fMRS during symptom provocation in OCD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49350

Enrollment

Registered

2017-02-20

Start date

2018-09-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

alcoholism contamination fear | alcohol addiction Obsessive-compulsive disorder

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with OCD (18 - 70 years) according to the DSM-5 criteria (American Psychiatric Association, 2013), with a Y-BOCS score of * 16. Age, gender and education matched healthy control participants free from psychiatric, neurological or severe somatic disorders.

Exclusion criteria

Exclusion criteria: Contraindications for MRI examination; e.g. metal in the body, claustrophobia. Problems with or shortness of breath when lying flat for 60 minutes. Traumatic brain injury involving a cerebral contusion with 1) loss of consciousness for more than 15 minutes and 2) post-traumatic amnesia of more than one hour.

Design outcomes

Primary

Measure	Time frame
The change in the concentration of glutamate in the LOC when viewing disorder-specific visual stimuli (versus neutral stimuli) in patients with OCD compared to healthy controls.	—

Secondary

Measure	Time frame
* The change in the concentration of GABA in the LOC when viewing disorder-specific visual stimuli (versus neutral stimuli) in patients with OCD compared to healthy controls. * Changes in brain activity in the LOC when viewing disorder-specific visual stimuli (versus neutral stimuli) by patients with OCD and healthy controls. * Relationship between change in glutamate and GABA concentration and change in brain activity in the LOC when viewing disorder-specific visual stimuli in patients with OCD compared to healthy control participants.	—

Measure

Time frame

* The change in the concentration of GABA in the LOC when viewing disorder-specific visual stimuli (versus neutral stimuli) in patients with OCD compared to healthy controls. * Changes in brain activity in the LOC when viewing disorder-specific visual stimuli (versus neutral stimuli) by patients with OCD and healthy controls. * Relationship between change in glutamate and GABA concentration and change in brain activity in the LOC when viewing disorder-specific visual stimuli in patients with OCD compared to healthy control participants.

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Countries

Netherlands

Outcome results