Capillary malformations, from genotype to phenotype: a focus on endothelial function

Capillary malformations, from genotype to phenotype: a focus on endothelial function - ACME (Amsterdam Capillary Malformation Evaluation) study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49348

Enrollment

Registered

2021-01-16

Start date

2021-04-06

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Capillary malformation port wine stain

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients with capillary malformations currently undergoing lasertherapy at the Amsterdam UMC location AMC.

Exclusion criteria

Exclusion criteria: Children and incapacitated patienten. Patients with a mix of different vascular malformations.

Design outcomes

Primary

Measure	Time frame
The main study parameter is the presence of the GNAQ, GNA11, RASA1 or PIK3CA gene mutation in study participants.	—

Secondary

Measure	Time frame
The secondary parameter is the biochemical profile, barrier function, angiogenic sprouting capacity and wound healing properties of endothelial cells from blood vessels of port wine stains.	—

Countries

Netherlands

Outcome results