Autism Spectrum Disorder
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: High-risk infants Age between 18 months and 24 months old At least one of the parents understands and speaks Dutch Positive screen on the Communication and Social development Signals (CoSoS) (with a score >=3) Caregiver and/or well-baby office professional (doctor, nurse) has ASD-specific concerns about their child Low-risk infants Age between 18 months and 24 months old At least one of the parents understands and speaks Dutch Negativescreen on the Communication and Social development Signals (CoSoS) (with a score
Exclusion criteria
Exclusion criteria: High-risk infants Diagnosis of epilepsy or history of fits/convulsions in infant (not including febrile convulsions); Known presence of genetic syndrome (in proband or infant) clearly related to ASD (e.g. TSC, FXS, 22q11, 16p11.2, Rett*s) Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health care professional) Infant was born prematurely (pre 36 weeks) Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care. Low-risk infants Diagnosis of epilepsy or history of fits/convulsions in infant; Known presence of genetic syndrome (in proband or infant) clearly related to ASD (e.g. TSC, FXS, 22q11, 16p11.2, Rett*s) Presence of known significant uncorrected vision or hearing impairment in infant (reported to parent by a doctor or health care professional) Infant was born prematurely (pre 36 weeks) Infant is looked after by the state (e.g. foster care), or other situation in which neither birth parent is involved in the infant*s care. Presence of known significant developmental or medical condition in infant likely to affect brain development or infant*s ability to participate in the study (e.g. Cerebral Palsy, Down*s syndrome, cystic fibrosis) Presence of ASD in 1st degree relatives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioural Communication and Social development Signals (CoSoS) Social Responsiveness Scale (SRS) Autism Diagnostic Observation Schedule (ADOS-2) EEG/Eye-Tracking Amplitude/latency of event-related potentials (ERPs) to visual and auditory stimuli Evaluation of EEG power (time frequency analysis) Location of eye gaze and fixation duration (eye-tracking) | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed