The THYRO-Dynamics study: Is the dynamics of thyroid hormones during cancer treatment in children adaptive or disruptive? - a prospective evaluation

The THYRO-Dynamics study: Is the dynamics of thyroid hormones during cancer treatment in children adaptive or disruptive? - a prospective evaluation - The THYRO-Dynamics study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49298

Enrollment

600

Registered

2019-12-13

Start date

2020-01-21

Completion date

Unknown

Last updated

2024-11-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypothyroidism non-thyroidal illness Thyroid dysfynction

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Children (

Exclusion criteria

Exclusion criteria: - Patients known with previous thyroid disease and receiving thyroid hormone substitution therapy - Patients diagnosed with Down Syndrome or Cowden syndrome - Patients known with or suspicious for MEN I or II syndrome - History or neck radiation or MIBG treatment - Diagnosis of pituitary tumor, craniopharyngioma

Design outcomes

Primary

Measure	Time frame
1. Prevalence of hypothyroidism (% of study cohort) defined as TSH > reference interval (5.0 mU/L) at the four time points 2. Severity of hypothyroidism at the 4 time points defined as: - Mild (TSH> 5, FT4 within the reference ranges) - Moderate (TSH > 10 mU/L, FT4 within reference ranges) - Severe (TSH above 10 mU/L, FT4	—

Secondary

Measure	Time frame
1. Prevalence of non-thyroidal illness (% of study cohort) defined as FT4 35 U/mL (ELiA)).	—

Countries

Netherlands

Outcome results