Study of expression of and immunity against neoantigens in patients with constitutional mismatch repair deficiency (CMMR-D) syndrome

Study of expression of and immunity against neoantigens in patients with constitutional mismatch repair deficiency (CMMR-D) syndrome - Immunity against neoantigens in CMMR-D

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49277

Enrollment

Registered

2020-07-20

Start date

2021-03-11

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bi-allelic Lynch syndrome Biallelic MisMatch Repair Deficiency (BMMRD)

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Patients with genetically proven Constitutional Mismatch Repair Deficiency (CMMRD) • Signed informed consent

Exclusion criteria

Exclusion criteria: • Any form of comorbitity interfering with safe collection of blood • Having objectives against coded storage of tissue

Design outcomes

Primary

Measure	Time frame
The primary endpoints of the study are the identification of neoantigens on different tumors of CMMR-D patients and the detection of pre-existing immune responses against neoantigens	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results