Parkinson's Disease
Conditions
Interventions
Participants will perform alternate (scheme will be ABACA or ACABA) schedules
of 30 minute sessions of B (HIIT) or 50 minute sessions of C (CAE 3x / week for
4 weeks) separated by baseline (A) perio
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1) diagnosis of PD according to brain bank criteria, 2) Hoehn-Yahr stage I (n21) and 4) able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) history of neurologic deficits other than PD, 2) severe fluctuating responses to medication, 3) psychiatric, musculoskeletal, cardiac or metabolic disorders prohibiting participation in intensive exercise training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome measures include disease status (UPDRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| blood biomarkers for plasticity (BDNF and Neurofilament Nfl), and measures for walking and balance, as well as cognition, mood and biorhythm (sleeping problems). | — |
Countries
Netherlands
Outcome results
None listed