Neurofibromatosis type 1 Von Recklinghausen disease
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age; between 18-55 years at inclusion - Being capable of providing written informed consent - Ability to understand the Dutch language - Healthy (no history of neurological or psychiatric disorders) - NF1 patients with a genetically or clinically confirmed diagnosis
Exclusion criteria
Exclusion criteria: - Use of psychoactive agents - History of or current presence of neurological or psychiatric disorders (excluding a history of attention deficit disorder or autism for the NF1 patients) - Other neurological illness influencing the functioning of the central nervous system or visual tract involved in the VEP recordings. - Neurological illness of the peripheral nervous system involving the sensory or visual function of the eyes. - Segmental NF1 - Severe visual problems or blindness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasticity as measured by the change in VEP peak amplitudes at T1, T2 and T3 after a modulation block of 10 minutes checkerboard reversals compared to the baseline measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| - VEPs parameters, such as latency and peak amplitudes of P100, at baseline measurements of patients and controls. - Parameters of visual information processing, such as reaction time, accuracy and speed of the eye movements, using a remote eye tracker - Relationships between cortical plasticity as measured by an increase in VEP peak amplitudes over time, and the parameters of visual information processing. | — |
Countries
Netherlands
Outcome results
None listed