REgistry of Pediatric Sjögren syndrome in Umcg- LongiTudinal (REPSULT)

REgistry of Pediatric Sjögren syndrome in Umcg- LongiTudinal (REPSULT) - REPSULT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49266

Enrollment

Registered

2020-04-29

Start date

2020-06-04

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjogren syndrome

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Confirmed or probable SS diagnosed before the age of 17 years.

Exclusion criteria

Exclusion criteria: Subjects who are impaired or incapable of completing cohort-related assessments Serious comorbidity or laboratory abnormalities that, in the opinion of the investigator, unacceptably increase the burden or risk of participation in the cohort.

Design outcomes

Primary

Measure	Time frame
Aims: 1. Define disease presentation of children with SS-like complaints 2. Evaluate current adult classification criteria in pedSS patients 3. Analyze the genetic constitution of pedSS 4. Assess essential biomarkers (of adult SS) in children with SS 5. Analyze and describe the clinical course and HRQoL of pedSS 6. Identify predictors of MALT lymphoma in pedSS Parameters Clinical and patient-reported parameters, salivary and tear gland function, ultrasound and histopathology of salivary glands, laboratory parameters, immunological parameters in serum, saliva and tears, and genetic markers.	—

Measure

Time frame

Aims: 1. Define disease presentation of children with SS-like complaints 2. Evaluate current adult classification criteria in pedSS patients 3. Analyze the genetic constitution of pedSS 4. Assess essential biomarkers (of adult SS) in children with SS 5. Analyze and describe the clinical course and HRQoL of pedSS 6. Identify predictors of MALT lymphoma in pedSS Parameters Clinical and patient-reported parameters, salivary and tear gland function, ultrasound and histopathology of salivary glands, laboratory parameters, immunological parameters in serum, saliva and tears, and genetic markers.

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Countries

Netherlands

Outcome results