Bronchopulmonary dysplasia underdeveloped lungs
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: Patients: diagnosis of BPD according to NHI criteria, age between 6 and 16 years, (in half of the BPD patients,n
Exclusion criteria
Exclusion criteria: Patients: contra- indications for MRI, inability to follow instructions in the MRI, current severe lung infection (respiratory distress, severe coughing, antibiotic use for lung infection), chronic oxygen need, Premature non- BPD patients: contra- indications for MRI, inability to follow instructions in the MRI, current severe lung infection (respiratory distress, severe coughing, antibiotic use for lung infection), chronic oxygen need, diagnosis of BPD, Healthy volunteers: contra- indications for MRI, inability to follow instructions in the MRI, current severe lung infection (respiratory distress, severe coughing, antibiotic use for lung infection), chronic oxygen need, born at a gestational age of less than 37 weeks, presence of pulmonary comorbidities (asthma, cystic fibrosis, interstitial lung disease etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint of this study is the ability of the MRI protocol to detect structural lung changes related to BPD as established using the VIBE- scoring system, evaluating normal lung tissue, low intensity regions, ventilation defects, presence of airway wall thickening, consolidations and severity of architectural distortion. | — |
Secondary
| Measure | Time frame |
|---|---|
| A technical qualitative assessment of the MRIs will be done. The MRI findings will be correlated to spirometry data, MBW measurements and compared to the CT findings. | — |
Countries
Netherlands
Outcome results
None listed