Assessment of myocardial function, metabolism, and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM

Assessment of myocardial function, metabolism, and perFUSION in early and advanced disease stages of Hypertrophic CardioMyopathy: FUSION-HCM - FUSION-HCM

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49221

Enrollment

105

Registered

2020-08-24

Start date

2019-12-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enlarged heart muscle disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: MYBPC3 mutation carrier MYH7 mutation carrier Genotype-negative first degree relative of a MYBPC3 or MYH7 mutation carriers

Exclusion criteria

Exclusion criteria: >=65 years old Diabetes mellitus Pregnancy Claustrophobia Pacemaker/ICD Renal insufficiency 30 kg/m2 Left bundle branch block Obstructive coronary artery disease Atrial fibrillation Hormone replacement therapy

Design outcomes

Primary

Measure	Time frame
myocardial fatty acid oxidation, uptake and esterification, glucose uptake en oxidation, perfusion, function and volume parameters of the heart	—

Secondary

Measure	Time frame
biomarker analysis	—

Countries

Netherlands

Outcome results