Liver metastases
Conditions
Interventions
Pancreatic cancer
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - 18 years and older - clinical suspicion of pancreatic cancer - written (signed and dated) informed consent
Exclusion criteria
Exclusion criteria: - Previous treatment for pancreatic cancer (e.g. chemotherapy, radiotherapy, surgery, ablation therapy) - Concomitant malignancies, except for adequately treated basocellular carcinoma of the skin or in situ carcinoma of the cervix uteri. Subjects with prior malignancies must be disease-free for at least 5 years - Contra-indications to undergo CT (due to e.g. extreme claustrophobia, untreatable contrast allergy, renal function impairment) - Contra-indications to undergo MRI (due to e.g. claustrophobia, untreatable contrast allergy, or not MRI compatible medical devices) - Insufficient command of the Dutch language to be able to understand the patient information or fill in the questionnaires - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of CECT and CE-DW-MRI for the detection of liver metastasis. | — |
Secondary
| Measure | Time frame |
|---|---|
| - sensitivity and specificity for CT and MRI to assess local resectability for all patients that underwent surgery - inter-observer variability for detection of liver metastases - median and one year survival - disease free survival - difference in overall survival in patients with few and many (>5) liver metastases - effect on patient management of early detection of liver metastases - cost effective analysis and budget impact analysis - to evaluate the effect of disease progression and metastatic burden in relation to tumor markers (Ca19.9 and CEA) | — |
Countries
The Netherlands
Outcome results
None listed