Neutrophil granulocyte membrane-based biomarker discovery for discrimination between acute bacterial versus acute viral infection: a pilot study.

Neutrophil granulocyte membrane-based biomarker discovery for discrimination between acute bacterial versus acute viral infection: a pilot study. - Levels study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49203

Enrollment

Registered

2019-02-05

Start date

2019-02-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial and viral respiratory infections

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: Adult (18 or above) participants with a suspected respiratory tract infection (pneumonia defined as respiratory complaints) presenting with fever (Temperature >37.7), at the Leiden University Medical Center, who will be admitted to the hospital, mentally competent., Healthy controls: adult (18 or above), temperature

Exclusion criteria

Exclusion criteria: Relation with the PI or the relevant department The participant is under treatment of immunosuppressive agents and/or antihistamines The participant is treated with chemotherapeutics The participant is treated with intravenous medication The participant has leukopenia (

Design outcomes

Primary

Measure	Time frame
Membrane bound proteins (biomarkers) on neutrophils and CD64 expressing cells. (spectrum of proteins as determined by proteomics)	—

Secondary

Measure	Time frame
Analysis of previously studied serum markers CRP and IP-10 using a rapid Point of Care (POC) lateral flow test and multiplex cytokine analysis	—

Countries

Netherlands

Outcome results