Male-female differences in immunohistological and biomechanical properties of the thoracic aorta

Male-female differences in immunohistological and biomechanical properties of the thoracic aorta - MAFATS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49187

Enrollment

Registered

2020-11-17

Start date

2022-02-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aortic aneurysm aortic dilatation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Adult patients (>= 18 years old) who have a thoracic aortic aneurysm and are scheduled for elective thoracic aortic surgery

Exclusion criteria

Exclusion criteria: Connective tissue disease (e.g. Marfan and Ehlers-Danlos syndromes)

Design outcomes

Primary

Measure	Time frame
Male-female differences in aortic wall structure: smooth muscle cell differentiation, presence of macrophages, endothelial and smooth muscle cell activation and extracellular matrix. Male-female differences in biomechanical properties of the aortic wall (strength and elasticity). Relation of these properties to sex hormone and sRAGE levels in blood and aortic diameter.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results