hypercoagulability - coagulation disorder
Conditions
Interventions
The volunteers in our study will experience oxygen deprivation by up the
mountain. This will be done passively and actively by walking up the mountain.
Blood samples will be taken via venipuncture.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Healthy * Age between 18 and 50 years old
Exclusion criteria
Exclusion criteria: * Previous history of cardiovascular disease, pulmonary disease, bleeding disorder or venous thromboembolism * Medication interfering with blood coagulation (low molecular weight heparins, vitamin K antagonists, direct oral anticoagulants, non-steroidal anti-inflammatory drugs) * Impaired mobility * Active smoking * Not passing medical assessment (see section 3) * Disapproval of contacting general practitioner in case of abnormalities found during medical assessment or during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ATP release from platelets and thrombin generation in whole blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Thrombin generation in platelet poor plasma, platelet function test in whole blood, blood count and vital signs (oxygen saturation, heart rate and blood pressure). | — |
Countries
Netherlands
Outcome results
None listed