experimentele pruritus experimental pruritus itch
Conditions
Interventions
After switching off the SCS or DRGS, histamine will be applied percutaneously
to a healthy area of skin innervated by the neurostimulator, as well as to a
healthy area of skin not innervated by the
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Good effect (>= 50% decrease of pain) of spinal cord stimulation (SCS) or dorsal root ganglion stimulation (DRGS) treatment. - The area innervated by the SCS or DRGS must extend to a healthy, pain-free, uninterrupted area of skin of at least 10x20cm - Contralaterally, an equal, uninterrupted, healthy area of skin must be available; this must not be innervated by the stimulator. - Patient must have no objections against switching off his or her device, for up to one hour. - Age >=18 years - No ongoing itch perception
Exclusion criteria
Exclusion criteria: - Generalized skin disorder, - Systemic disease associated with pruritus, - Complex regional pain syndrome - Allergy or hypersensitivity - Contra-indication for histamine administration, such as mastocytosis - Use of opioids - Use of oral antihistamines, corticosteroids or other (immunosuppressive) drugs that might prevent potential participants from developing a flare.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Itch intensity will be recorded using a visual analog scale (VAS). Patients* VAS score will be noted at baseline, after switching off of the neurostimulator, 15 minutes after application of histamine, and 1, 5, 10, 15 and 30 minutes after the stimulator has been switched on. All measurements will be noted for both sides, separately. | — |
Secondary
| Measure | Time frame |
|---|---|
| The size of the flare will be measured at all timepoints after application of histamine. At all timepoints after histamine application, character and variance of itch perception will be determined, by means of a questionnaire. All measurements will be noted for both sides, separately. | — |
Countries
Netherlands
Outcome results
None listed