eiwitvertering bij gezonde mensen normal digestion
Conditions
Interventions
The subjects will drink two 600ml dairy-based drinks containing casein and
matched on macronutrient composition but differing in mineral composition.
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Male * 18 - 55 yr old * In self-reported health * BMI between 18,5 and 25kg/m2
Exclusion criteria
Exclusion criteria: * Bovine milk allergy or intolerance (self-reported) * Being vegan * Lactose intolerance (self-reported) * Disorders of the upper ingestive tract resulting in difficulties chewing/swallowing. * Unexplained weight change * Gastric disorders or regular gastric complaints, heart burn for example * Use of proton pump inhibitors or other medication which alters the normal function-ing of the stomach * Use of a medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. * Use of a medical drug use that influence the GI tract*s microbiota: antibiotic use within 1 months prior to the pre-study screenings day * Use of recreational drugs within 1 month prior to the pre-study screenings day * Alcohol consumption of more than 14 glasses/week * Smoking * Having a contra-indication to MRI scanning (including, but not limited to): * Pacemakers and defibrillators * Intraorbital or intraocular metallic fragments * Ferromagnetic implants * Claustrofobic * Not wanting information at unexpected findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Postprandial plasma amino-acid concentrations 2. Gastric emptying rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Glucose and insulin 2. Coagulation and other product instabilities if visible 3. Fullness, bloating, nausea ratings obtained after each MRI measurement | — |
Countries
Netherlands
Outcome results
None listed