Association of Radiation-induced Lymphocyte Apoptosis with Radiation Induced Fibrosis after Breast Conserving Therapy

Association of Radiation-induced Lymphocyte Apoptosis with Radiation Induced Fibrosis after Breast Conserving Therapy - RILARIF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49154

Enrollment

Registered

2020-08-05

Start date

2020-09-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radiation induced fibrosis radiation induced fibrosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Females and age 18 years or older History of BCT with radiation therapy for non-metastatic, histologically proven invasive breast cancer (pT1-3N0-2a) Having either * grade 1 (controls) or * grade 3 (cases) fibrosis on the LENT SOMA scale

Exclusion criteria

Exclusion criteria: Males

Design outcomes

Primary

Measure	Time frame
The primary study outcome is the frequency of radiation-induced apoptosis of CD4+ and CD8+ T-lymphocytes in cases and controls.	—

Secondary

Measure	Time frame
The secondary study outcomes are treatment and patient related risk factors and health related quality of life.	—

Countries

Netherlands

Outcome results