Diagnosing small fiber neuropathy in sarcoidosis patients using corneal confocal microscopy

Diagnosing small fiber neuropathy in sarcoidosis patients using corneal confocal microscopy - SFN in patients with sarcoidosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49119

Enrollment

100

Registered

2020-10-29

Start date

2022-01-26

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

painfull neuropathy - autonomic neuropathy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age 18-75 years * Patients with sarcoidosis and SFN symptoms * Patients with sarcoidosis and without SFN symptoms

Exclusion criteria

Exclusion criteria: * Ocular disease * Ocular surgery * Allergy to the anaesthetic or contents of eye gel * Diseases with possible polyneuropathy o Diabetes (type I & type II) o Vitamin B12 deficiency o Metabolic syndrome o Impaired glucose intolerance * Clinical relevant abnormal history of physical and/or mental health * Pregnancy * High alcohol intake

Design outcomes

Primary

Measure	Time frame
Corneal CNFD, CNFD, CNFB and CNFT	—

Secondary

Measure	Time frame
skin wrinkling grades: grade 0-4 Electrochemical skin conductance Blood pressure (mmHg) SFNSL-score: 48 SFN confirmed Phenotypes: SFSCD, SFMNP, SFMWP and SFMAD	—

Countries

Netherlands

Outcome results