Livestock Farming and Neighbouring Residents* Health: Part 3

Livestock Farming and Neighbouring Residents* Health: Part 3 - VGO-3 study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49112

Enrollment

1750

Registered

2020-02-12

Start date

2020-12-10

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

microbioom infection of the lungs pneumonia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: (Patient population: being diagnosed with pneumonia (ICPC-code R81) at GP-office) Control group: participated in VGO-1-study Goat farmers: working on a goat farm

Exclusion criteria

Exclusion criteria: Control group: no exclusion criteria. There are contra-indications for performing lung function testing: - Heart failure including heart attack in the last three months - Chest or abdominal surgery in the past 3 months - Ascending aortic aneurysm - Haemoptysis - A brain, ear or eye surgery in the past 1 month - Usage of immunsuppressants/ chemotherapeutics - Immunodeficiency - Pregnancy (last trimester) - Participants discomfort (diarrhea, vomiting, common cold) Goat farmers: not able to communicate in Dutch

Design outcomes

Primary

Measure	Time frame
Control subjects, goat farmers (and patients) • Pathogen detection in nasopharyngeal swab by multiplex PCR of 33 respiratory pathogens (for details, see 8.3); • Coxiella burnetii detection in nasopharyngeal swab by PCR; • Oropharyngeal microbiota composition (16S rRNA sequencing); • In subpopulation: nasopharyngeal/oropharyngeal virome and metagenome. • serum response to SARS-CoV-2 Control group • Pre-bronchodilator lung function; • Respiratory symptoms (questionnaire). Goat farmers • Serology on farm related pathogens including Coxiella burnetii; • Serology on farm related thermophilic bacteria as markers for Hypersensitivity Pneumonitis (Extrinsieke Allergische Alveolitis).	—

Measure

Time frame

Control subjects, goat farmers (and patients) • Pathogen detection in nasopharyngeal swab by multiplex PCR of 33 respiratory pathogens (for details, see 8.3); • Coxiella burnetii detection in nasopharyngeal swab by PCR; • Oropharyngeal microbiota composition (16S rRNA sequencing); • In subpopulation: nasopharyngeal/oropharyngeal virome and metagenome. • serum response to SARS-CoV-2 Control group • Pre-bronchodilator lung function; • Respiratory symptoms (questionnaire). Goat farmers • Serology on farm related pathogens including Coxiella burnetii; • Serology on farm related thermophilic bacteria as markers for Hypersensitivity Pneumonitis (Extrinsieke Allergische Alveolitis).

—

Secondary

Measure	Time frame
Control group • Atopic status, specific serum IgE to a panel of common inhalant allergens namely: grass, tree, house dust mite, cat and dog; Goat farmers • Respiratory symptoms and exposure related to type of farm work (questionnaire); • Gut microbioata composition in faecal sample (16S rRNA sequencing);	—

Countries

Netherlands

Outcome results