Corona virus
Conditions
Interventions
Patients will receive CPAP with high FiO2. With CPAP a continuous airflow is
provided through a well-fitting face mask.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - > 18 years of age - proven COVID-19 positive disease - being admitted to the hospital with oxygenation problems, needing oxygen * 6L/min - Patients need to be able to read and understand the patient information letter and sign informed consent.
Exclusion criteria
Exclusion criteria: * Patients with severe comorbid pulmonary disease or other diseases leading to hypercapnic respiratory failure * * Patients in instable condition (hypotensive, cardiac failure/arrhythmia, more than 1 organ failure, upper airway obstruction, very high work of breathing (breathing frequency at rest persistently > 30 breaths/min) * Unable to fit mask * Patients who are vomiting * Agitated, uncooperative patients * Patients who are unable to protect their airway (for example swallowing impairment) * Patients with excessive secretions that cannot be managed adequately * Patients with recent upper airway of upper gastro-intestinal surgery * Patients with severe skin disease making attachment of the ExG skin electrodes impossible * Pregnant patients * Patients not being able to read and understand the patient information letter and sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate how effective the addition of several levels of CPAP on top of high oxygen supplementation is on oxygenation, defined peripheral oxygen saturation (SpO2). | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate how effective the addition of several levels of CPAP on top of high oxygen supplementation is on - work of breathing, measured with surface EMG and by measuring breathing frequency. EMG mesaurements will be performed with the ExG measurement devoce of ItoM, This device is not CE certified yet, but is extensively tested in healthy persons and has no risks. - gas exchange: SpO2/FiO2 ratio and transcutaneously measured PtCO2 - Patient dyspnea measured with a Borg scale. - Patient comfort measured with a Borg scale. | — |
Countries
Netherlands
Outcome results
None listed