Ventilator-associated injury (VAI) in chronic home mechanical ventilation: a paradigm switch in order to improve ventilatory support

Ventilator-associated injury (VAI) in chronic home mechanical ventilation: a paradigm switch in order to improve ventilatory support - VAI-HMV

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON49038

Enrollment

Registered

2020-08-05

Start date

2020-09-01

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. RLD: probable or confirmed diagnosis of interstitial pulmonary fibrosis (IPF) or other fibrotic lung disease of unknown origin. 2. COPD: GOLD stage III or IV 3. Being listed for lung transplantation

Exclusion criteria

Exclusion criteria: 1. Concomitant neuromuscular or systemic/collagen-vascular disease 2. Prior lung surgery or lung volume reduction treatment 3. Being unable to understand the patient information and consent for the study

Design outcomes

Primary

Measure	Time frame
The study is an exploratory pilot study. We will investigate both contractile strength and the structure of single diaphragm and intercostal muscle fibres as well as lung injury; i.e. alveolar structure and damage and inflammation in the alveoli.	—

Secondary

Measure	Time frame
The study is an exploratory pilot study. We will investigate both contractile strength and the structure of single diaphragm and intercostal muscle fibres as well as lung injury; i.e. alveolar structure and damage and inflammation in the alveoli.	—

Countries

Netherlands

Outcome results