blood poisoning Septic shock
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - *18 years old - Quick Sequential Organ Failure Assessment score (qSOFA score) *2 with suspicion of infection - MAP 2 mmol/L despite volume resuscitation, requiring vasopressors - Inclusion within 12 hours after arriving on the Intensive Care Unit
Exclusion criteria
Exclusion criteria: - Absence of informed consent - No arterial catheter placement * 12 hours after arriving on the Intensive Care Unit - Transfer from another hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Transendothelial electrical resistance (TER) Electric Cell-substrate Impedance Sensing (ECIS) will be used to quantify endothelial barrier integrity. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Endothelial barrier function Transwell assays will be used to study endothelial permeability and microscopic techniques to study endothelial junction formation and linearity. - Markers of endothelial activation and inflammation - Demographic data: (admission) Age, gender, specific reason for admission, medication use, comorbidities (acute, chronic) - Clinical data: Complete blood count, markers of biochemistry on inclusion day (as determined as part of standard care), APACHE II score, daily SOFA score, mechanical ventilation (yes/no), mechanical ventilation duration (days), occurrence of ARDS (yes/no), ARDS score, inotropic therapy (yes/no), duration of inotropic/vasopressor support, renal failure according to the RIFLE score (yes/no), occurrence of DIC (yes/no), DIC score, anticoagulant use, site of infection, culture results, 30 day mortality, length of ICU stay (days), hospital length of stay (days), red blood cell units transfused, plasma units transfused, platelets units transfused | — |
Countries
Netherlands
Outcome results
None listed