classic galactosemia GALT deficiency
Conditions
Interventions
The intervention consists of tACS at beta and theta frequency to hopefully
ameliorate the motor and speech problems in patients with CG.
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patient group: The patient may participate in the study, if they meet these criteria: - Adult age: 18 years or older - GALT enzyme activity below 10% and/or GALT gene severe disease causing mutations - Motor sequencing and/or word productions problems - Documented motor and language impairments - Capable of giving informed consent - The participants are screened pre and post intervention using standardized tests. Participants with abnormal scores in cognitive and/or motor domains are eligible. Control group: Healthy controls are included if they meet the following criteria: - Adult age: 18 years or older - No motor, language and/or cognitive impairments - Capable of giving informed consent
Exclusion criteria
Exclusion criteria: - Motor and language problems due to other causes - Eczema - Psoriasis - Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Language/speech task Reaction times and accuracy will be compared pre, during and post stimulation within the CG group and between groups. To validate a relation of theta and beta oscillation on language problems, we will compare the EEG theta and beta power spectrum of CG and healthy controls during the active language task and in resting state data. To investigate the relation between tACS and brain oscillation we will compare theta and beta power in pre and post stimulation EEG. To validate a relation of speech behavior and tACS we will investigate the relation of theta power pre-post difference and behavior pre-post difference in both groups of participants. | — |
Countries
Netherlands
Outcome results
None listed