allergic esophagitis Eosinophilic esophagitis
Conditions
Interventions
EoE patients will undergo two gastroscopies with allergen provocation tests. In
one gastroscopy patients undergo esophageal allergen injections as described in
our pilot study (NL54305.018.15 / METC
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Eosinophilic esophagitis patients - Previous diagnosis of active EoE confirmed by histopathology e.g. presence of > 15 eosinophilic granulocytes per high power field (hpf) in mid or proximal esophageal biopsies - Written informed consent - Age 18-75 years Non- eosinophilic esophagitis patients - Patients that undergo a gastroscopy for other indications than esophageal complaints - Written informed consent - Age 18 * 75 years
Exclusion criteria
Exclusion criteria: Eosinophilic esophagitis patients - Inability to stop topical corticosteroids - Inability to stop beta-blockers and ACE inhibitors - Use of oral or systemic antihistaminics, oral cromoglicates, systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the month preceding the study - Proven gastroesophageal reflux disease or other cause for esophageal eosinophilia - History of peptic ulcer disease - History of Barrett*s esophagus - History of GI cancer - ASA class III, IV or V - History of anaphylaxis - History of a severe systemic reaction to previous allergy tests (grade 3 or 4) Non- eosinophilic esophagitis patients - Symptoms of esophageal dysfunction - History of esophageal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visible response to allergen provocation in the esophagus, defined as early phase response | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Immune response after allergen injection and flush of allergens, defined as activated immune cells observed in biopsies 2. Immune response to added allergens of esophageal mucosal cells in culture medium, defined as release of cytokines 3. Esophageal motility changes after allergen exposure | — |
Countries
Netherlands
Outcome results
None listed