Neurotoxic changes in cerebral glucose metabolism during anaesthesia and major surgery; is the polyol pathway activated?

Neurotoxic changes in cerebral glucose metabolism during anaesthesia and major surgery; is the polyol pathway activated? - Changes in cerebral glucose metabolism during anaesthesia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON48939

Enrollment

Registered

2018-10-25

Start date

2019-05-22

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glucose metabolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - informed consent - age >18 years - undergoing elective thoracic aortic surgery

Exclusion criteria

Exclusion criteria: - pre-existing brain disease - diabetes mellitus - unable to understand or fill-in questionnaires in Dutch

Design outcomes

Primary

Measure	Time frame
The change in cerebral glucose metabolism in the perioperative period as measured by the difference in CSF/plasma ratio of glucose at different points in time.	—

Secondary

Measure	Time frame
- Correlation of perioperative change (increase) of plasma glucose with change in CSF glucose - Difference in sorbitol and fructose concentration after induction of anaesthesia as compared to the awake state - Difference in sorbitol and fructose concentration during surgery as compared to the awake state - Cortisol plasmalevels for the given points in time? - C-reactive protein (CRP) plasmalevels for the given points in time?	—

Measure

Time frame

- Correlation of perioperative change (increase) of plasma glucose with change in CSF glucose - Difference in sorbitol and fructose concentration after induction of anaesthesia as compared to the awake state - Difference in sorbitol and fructose concentration during surgery as compared to the awake state - Cortisol plasmalevels for the given points in time? - C-reactive protein (CRP) plasmalevels for the given points in time?

—

Countries

Netherlands

Outcome results